Like most anaesthetics, propofol is a γ-aminobutyric acid (GABA) receptor agonist. It has a favourable pharmacokinetic (PK) and pharmacodynamic (PD) profile, which has resulted in it becoming the most commonly used intravenous anaesthetic for the past three decades [ 2, 3, 4, 5, 6, 7 ].

The pharmacokinetics of propofol were best described by a three-compartment model. Weight was found to be a significant covariate for elimination clearance, the two intercompartmental clearances, and the volumes of the central compartment, the shallow peripheral compartment, and the deep peripheral compartment; power functions with exponents smaller than 1 yielded the best results.

We successfully fitted a 3-compartment model to the data. Covariates were included in the model based on the BIC, evaluated for every possible combination of influence of a covariate on any of the 6 pharmacokinetic parameters. Dyck GB, Shafer SL. Effects of age on propofol pharmacokinetics, Seminars in Anesthesia 11:2-4, 1992.. Glass PS, Hardman D, Kamiyama Y, Quill TJ, Marton G, Donn KH, Grosse CM, Hermann D. Preliminary pharmacokinetics and pharmacodynamics of an ultra-short-acting opioid: remifentanil (GI87084B). Anesth Analg 77:1031-1040, 1993 Pharmacokinetics The pharmacokinetics of propofol are well described by a three compartment linear model with compartments representing the plasma, rapidly equilibrating tissues, and slowly equilibrating tissues. Following an IV bolus dose, there is rapid equilibration between the plasma and the brain, accounting for the rapid onset of anesthesia. Despite the very long elimination half-life, blood propofol concentrations appeared to approach steady state within 20 min rather than the 4-5 half-lives normally expected.

Pharmacokinetics and Pharmacodynamics of Propofol Microemulsion and Lipid Emulsion after an Intravenous Bolus and Variable Rate Infusion Materials and Methods. After obtaining the approval of the institutional review board of Asan Medical Center (Seoul, Results. Thirty-one volunteers (15 male and 5 Pharmacokinetics (PK) 5.1 Absorption Propofol is only suitable for intravenous use. It is not suitable for enteral or other routes of administration due to its bitter taste and low oral bioavailability caused by a high Pharmacokinetics and Pharmacodynamics of Propofol The pharmacokinetics of propofol were best described by a three-compartment model. Weight was found to be a significant covariate for elimination clearance, the two intercompartmental clearances, and the volumes of the central compartment, the shallow peripheral compartment, and the deep peripheral compartment; power functions with exponents smaller than 1 yielded the best results. Our clinical experiences regarding the use of propofol evaluated by the COMFORT-B in young children in the pediatric surgical intensive care unit (PSICU) have recently been published by Prins et al. 8In the current article, propofol pharmacokinetics and pharmacodynamics characterized by use of the COMFORT-B and BIS on the postoperative sleep pattern in nonventilated infants are described using population modeling, to select appropriate doses in infants and to support the safe and effective The pharmacokinetics and pharmacodynamics of propofol in a modified cyclodextrin formulation (Captisol) versus propofol in a lipid formulation (Diprivan): an electroencephalographic and hemodynamic study in a porcine model.

Propofol Pharmacokinetics and Pharmacodynamics Modelling The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

Propofol pharmacokinetics readily crosses the placenta; however, it is rapidly cleared from the neonatal circulation. The amount of propofol excreted into milk within 24 hours of induction of anesthesia dose not mandate discontinuation of breastfeeding. If you have any more questions on this topic or any other health related topic ask a Doctor here.

Age‐dependent development of acute tolerance to propofol and its distribution in a pharmacokinetic compartment‐independent rat model. JE Larsson, G

We believe that this pharmacokinetic characterization of propofol will help in better management of these patients undergoing surgery under total intravenous anesthesia (TIVA) in our setup. 12 ASA (American Society of Anesthesiologists) grade I patients, 5 to 12 years old planned for elective surgery will be 1995-12-01 2016-10-01 For propofol, significant decreases in the propofol C 50 for no response to calling the person by name, tolerance to shake and shout, and tolerance to tetanic stimulation were found at increasing effect-site concentration (remifentanil) as also found by Kern et al. 30 For sevoflurane, the influence of remifentanil on the sevoflurane C 50 values was variable, ranging from no influence for no Propofol plasma concentrations were determined from arterial blood samples. Pharmacokinetics were tested for linearity using the ratio of the concentrations at the end of the first and second infusion interval as a model independent criterion. Several linear and nonlinear models were investigated with population pharmacokinetic analysis. 2017-05-26 2020-08-25 1988-02-01 This study, however, shows that epidural blockade affects the pharmacokinetics of propofol through a reduction in propofol clearance. We successfully fitted a 3-compartment model to the data.

Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation. Se hela listan på drugs.com Models of propofol pharmacokinetics and pharmacodynamics developed in patients without brain pathology are widely used for target-controlled infusion (TCI) during brain tumour excision operations. The goal of this study was to determine if the presence of a frontal brain tumour influences propofol pharmacokinetics and pharmacodynamics and existing PK-PD model performance. Propofol pharmacokinetics readily crosses the placenta; however, it is rapidly cleared from the neonatal circulation. The amount of propofol excreted into milk within 24 hours of induction of anesthesia dose not mandate discontinuation of breastfeeding.
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After premedication with acepromazine and papaveretum, anaesthesia was induced with either propofol at 4 mg kg-1 intravenously (group 1) or with a mixture of propofol at 3 mg kg-1 and ketamine at 1 mg kg-1 intravenously (group 2). characterize propofol PK over a wide range of body weights. An allometric model using TBW as the size descriptor of volumes and clearances was superior to other size descriptors to characterize propofol PK in obese patients.
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23 Jun 2009 Though rare, propofol infusion syndrome (PRIS) is a cause of acute kidney injury in the appropriate ICU setting. As we all know, propofol is an

Patients were recruited after having been administered propofol for 24 h. Propofol Pharmacokinetics and Pharmacodynamics Modelling The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.

Propofol, marketed as Diprivan, among other names, is a short-acting medication that results in a decreased level of consciousness and a lack of memory for events. Its uses include the starting and maintenance of general anesthesia, sedation for mechanically ventilated adults, and procedural sedation.

Methods After craniofacial surgery, 22 of the 44 evaluated infants (aged 3-17 months) in the pediatric intensive care unit received propofol (2-4 mg . kg-1 . h-1) during a median of 12.5 h, based on the COMFORT-Behavior score. This interactive simulation of propofol pharmacokinetics is based on a 3-compartment model either from Gepts et al, Anesthesia & Analgesia 66:1256-63, 1987 (default) or Fechner et al, Anesthesiology 99:303-13, 2003.

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