GABRIEL Dammskyddsats, stötdämpare. OE 90 222 170 framaxel. Artikelnummer: GP130. Slut i lager. Meddela mig vid tillgänglighet. 373,87 kr -25%. 280,40 kr.
Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130.
All IL6ST products are produced in house and quality controlled. By immunoscreening a placenta cDNA expression library with antibodies to human gp130, followed by screening a myeloma cell line cDNA library, Hibi et al. (1990) cloned gp130. The deduced 918-amino acid protein has an N-terminal signal peptide, followed by a 597-amino acid extracellular region, a transmembrane domain, and a 277-amino acid cytoplasmic domain. Gp130.
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Glycoprotein gp130 has a molecular mass of 130–150 kDa; gp130 has the alternative names IL-6Rβ, CD130, and IL-6 signal transducer. The molecular cloning of human gp130cDNA was reported in 1990 (database accession, M57230). Macrophage recruitment is essential for heart regeneration through the secretion of OSM, which promotes cardiomyocyte proliferation. As the coreceptor of OSM, gp130 activation is sufficient to promote cardiomyocyte proliferation by activating Yap through Src during heart regeneration. gp130 is a pot … One typical example is a group of receptor systems for interleukin-6 (IL-6) and related cytokines that share gp130 as a signal transducer. This subset of cytokines, i.e., IL-6, IL-11, leukemia inhibitory factor, oncostatin M, ciliary neurotrophic factor, and cardiotrophin-1, are all pleiotropic, exhibiting overlapping biological activities, and are known to function also in the neuronal system.
OE 90 222 170 framaxel. Artikelnummer: GP130. Slut i lager.
allmänt förekommande signalomvandlande glykoprotein 130 (gp130) och signalomvandlare och -transkriptionsaktiverare 3 (Signal Transducer and Activator,
NEDD4L is reduced in the epidermis of psoriasis patients and negatively correlates with GP130 and p‐STAT3 Gp130 −/− embryos, which are generated by heterozygous crossing, also die between day 13 and term due to abnormal cardiac development . Therefore, although LIF binds LIFR and recruits GP130, the definitive role of LIFR and GP130 in implantation remains uncertain.
研究成果のポイント. シグナル伝達分子、gp130を共有するIL-6ファミリー サイトカインの機能の重複性と特異性について自己免疫疾患を例に
The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists. Production of recombinant gp130‐RAPS by baculovirus‐infected insect cells. A, Production of gp130‐RAPS by insect cells was confirmed by immunofluorescence staining.
2021-03-26 · The E3 ubiquitin ligase NEDD4L negatively regulates keratinocyte hyperplasia by inhibiting IL‐6/GP130/STAT3 signaling. NEDD4L directly interacts with GP130 and mediates its Lys‐27‐linked ubiquitination and proteasomal degradation. NEDD4L is reduced in the epidermis of psoriasis patients and negatively correlates with GP130 and p‐STAT3
Gp130 −/− embryos, which are generated by heterozygous crossing, also die between day 13 and term due to abnormal cardiac development . Therefore, although LIF binds LIFR and recruits GP130, the definitive role of LIFR and GP130 in implantation remains uncertain. gp130 antibodies were obtained from Cell Signaling Technology (Frankfurt am Main, Germany).
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The molecular cloning of human gp130cDNA was reported in 1990 (database accession, M57230). Macrophage recruitment is essential for heart regeneration through the secretion of OSM, which promotes cardiomyocyte proliferation.
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Comparative evaluation of gp130 signalling cytokines in human endothelial cells: evidence for both specific and overlapping molecular responses
To investigate whether eutopic endometrial expression of leukaemia inhibitory factor (LIF), LIF receptor (LIFR) and glycoprotein 130 (gp130) in subfertile women
cancer-associated fibroblasts (CAFs) triggers GP130/STAT3 signaling in prevents metastasis initiation ▻ A TGF-β/IL-11/GP130 signaling cycle confers
gp130 Inhibitor, SC144. REACH- registreringsnummer: Det finns inget registreringsnummer för denna substans eftersom substans en eller dess användning är
av L Runesson · 2010 — implantation, mediates its effect through LIF receptor and the coreceptor, gp130, and is down regulated by suppressors of cytokine signaling 1.
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Macrophage recruitment is essential for heart regeneration through the secretion of OSM, which promotes cardiomyocyte proliferation. As the coreceptor of OSM, gp130 activation is sufficient to promote cardiomyocyte proliferation by activating Yap through Src during heart regeneration. gp130 is …
Meddela mig vid tillgänglighet. 373,87 kr -25%. 280,40 kr. LRC · 4 Juni 2012 · #5,308. Tja, eftersom den förra bilden gick så snabbt kan jag ta en till, som nog är lite svårare: gp130.jpg Father: Claes Erik Andersson Born: 1848, Sweden Marr: 1876 Died: 1912. Mother: Karin Persdotter Born: 1854, Sweden Died: 1914, Sweden. Sven Elis Brodin 29Sanchez-Cuenca J, Martin JC, Pellicer A, Simon C: Cytokine pleiotropy and redundancy--gp130 cytokines in human implantation.
Gp130 engagement leads to activation of Src and JAK/Tyk tyrosine kinases, as well as the STAT family of transcription factors (4, 5). IL-6 is the prototypic gp130-cytokine and binds the gp130 receptor through three conserved epitopes (sites I, II, and III), of which site III is unique to gp130-cytokines (6–9).
The most well-known are interleukin IL-6 and IL-11, LIF, CT-1, OSM, and ciliary neurotrophic factor. 2016-01-01 2020-06-30 gp130 Inhibitor, SC144 - Calbiochem; Synonym: gp130 Inhibitor, SC144 - Calbiochem, SC144; Linear Formula: C16H11FN6O · xHCl; find Sigma-Aldrich-5.06387 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.
2. CORNU ALTERNO 500. Dépôt vente pour un client av S Spitsin · 2020 — Both recombinant proteins bound SIV gp130 in standard ELISA assays (not shown). All constructs were tested for their ability to neutralize SIV Abstrakt.